Importantly, these alterations are not uniform across the brain. Because higher cognitive functions require large—scale interactions across prefrontal cortical and hippocampal networks, selectively targeting an alteration within one region may not broadly restore function to improve cognition. One mechanism for decline that the PFC and HPC share, however, is a reduced ability to utilize glucose for energy metabolism. Thus, the current study used a ketogenic diet KD as a global metabolic strategy for improving brain function in young and aged rats. After 12 weeks, rats were trained to perform a spatial alternation task through an asymmetrical maze, in which one arm was closed and the other was open. Both young and aged KD-fed rats showed resilience against the anxiogenic open arm, training to alternation criterion performance faster than control animals. At the completion of behavioral testing, tissue punches were collected from the PFC for biochemical analysis.
Cunnane et al. Ketogenic diet and changes in sleep structures A few studies have implicated the benefits of KD in providing better sleeping patterns and improved cognitive function in patients with epilepsy. Four studies evaluated the cognitive impact of KD and showed a positive effect on cognition, in ageing animals [ 20, 23, 24, 27 ]. Thus, the relationship between APOE4 status and cognitive effects of metabolic interventions deserves further investigations. Edited by C. The publisher’s final edited version of this article is available at Epilepsy Res. While careful attention has been paid to the effects of KD upon seizure activity, less is known about its effects upon cognition. Pilot feasibility and safety study examining the effect of medium chain triglyceride supplementation in subjects with mild cognitive impairment: a randomized controlled trial. Age-related impairments in object-place associations are not due to hippocampal dysfunction.
Multiple forms of the ketogenic diet KD have been successfully used to treat drug-resistant epilepsy, however its mainstream use as a first-line therapy is still limited. Further investigation into its clinical efficacy as well as the molecular basis of activity is likely to assist in the reversal of any resistance to its implementation. We will also elucidate the role of KD in the interesting relationship between sleep, epilepsy and memory. Currently available evidence also indicates that, under appropriate control, and with further studies investigating any potential long-term side effects, the KD is also a relatively safe intervention, especially when compared to traditional anti-epileptic pharmacotherapeutics. The ketogenic diet KD is a regimen that constitutes a food supply of high-fat, medium-protein, and low-carbohydrates. The KD is so-termed, as maintenance on this diet induces and sustains a ketotic state in the body. The KD has been used to treat various forms of drug-resistant epilepsy. In the clinical setting, patients are usually given 1 g of protein per 1 kg of bodyweight, 5—10 g of carbohydrates, and the remainder of the necessary daily calories is given in the form of fat Kossoff,