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There was similarly no consistent effect of HC on expression of uncoupling proteins. The increase in the number of publications about l -Cys during the last two decades is meaningful and relevant Figure 3. However, we did not note any changes in SCD-1 expression in liver, muscle or adipose. Hepatic SCD-1 suppression is linked to hypermetabolic phenotypes associated with dietary restriction of the cysteine precursor methionine [12,25], and responds to cysteine supplementation of methionine-restricted rats [29]. Sekhar R. Mokhtari V. The main evidence reporting benefits of l -Cys usage is summarized. Geck R.