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Blood clots form when certain parts of your blood thicken, forming a semisolid mass. This process may be triggered by an injury or it can sometimes occur inside blood vessels that don’t have an obvious injury. Once these clots form, they can travel to other parts of your body, causing harm. Factors and conditions that can cause troublesome blood clots, as well as serious conditions that are associated with blood clots, include. Causes shown here are commonly associated with this symptom. Work with your doctor or other health care professional for an accurate diagnosis. Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission.